Ana ______ Panamá translates to "Ana [blank] Panama". The options are as follows.
es de - "[he/she] is from"
son de - "[they] are from"
vienen de - "[they] come from"
vienes - "[you] come" (informal)
As options 2 and 3 are plural conjugations, and option 4 is in second-person, the only correct option is option 1 - es de.
Answer:
es de
Ana es de Panamá.
