missdumas3686 missdumas3686
  • 17-11-2017
  • Chemistry
contestada

Cytotoxic T-lymphocytes produce a substance called _______, which creates holes in the cell membranes of target cells

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shinmin
shinmin shinmin
  • 27-11-2017

The answer is perforin. This is a pore creating cytolytic protein located in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin attaches to the target cell's plasma membrane, and oligomerises in a Ca2+ dependent way to create pores on the target cell.

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