Answer:
Holoenzyme is a catalytically active enzyme that consists of apoenzyme and cofactor. Cofactors can make reactions that cannot be done by standard twenty amino acids.
Coenzymes and cofactors are molecules that help an enzyme or protein to function appropriately. Coenzymes are organic molecules and quite often bind loosely to the active site of an enzyme and aid in substrate recruitment, whereas cofactors do not bind the enzyme.
